Klinghardt lecture 2002

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The Klinghardt Neurotoxin Elimination Protocol

Approved by: American Academy of Neural Therapy and Institute of Neurobiology (Bellevue, WA, USA) Institute for Neurobiologie (Stuttgart, Germany) Academy for Balanced NeuroBiology Ltd (London, United Kingdom)

This lecture was presented by Dietrich Klinghardt M.D., Ph.D. at the Jean Piaget Department at the University of Geneva, Switzerland Oct.2002 to physicians and dentists from Europe, Israel, several Arab countries and Asia, Updated 2006

What are Neurotoxins?

Neurotoxins are substances attracted to the mammalian nervous system. They are absorbed by nerve endings and travel inside the neuron to the cell body. On their way they disrupt vital functions of the nerve cell, such as axonal transport of nutrients, mitochondrial respiration and proper DNA transcription. The body is constantly trying to eliminate neurotoxins via the available exit routes: the liver, kidney, skin and exhaled air. Detox mechanisms include acetylation, sulfation, glucuronidation, oxidation and others. Often the host is triggered to produce neurotoxins (which are damaging to their own tissues) by the invading microbes through molecular trickery.

The liver is most important in the toxion elimination process. Here most elimination products are expelled with the bile into the small intestine and should leave the body via the digestive tract. However, because of the lipophilic/neurotropic nature of the neurotoxins, most are reabsorbed by the abundant nerve endings of the enteric nervous system (ENS) in the intestinal wall. The ENS has more neurons than the spinal chord.

From the moment of mucosal uptake the toxins can potentially take four different paths:

  1. neuronal uptake and via axonal transport to the spinal chord (sympathetic neurons) or brainstem (parasympathetics) – from here back to the brain.
  2. Venous uptake and via the portal vein back to the liver
  3. Lymphatic uptake and via the thoracic duct to the subclavian vein
  4. Uptake by bowel bacteria and tissues of the intestinal tract

Here is an incomplete list of common neurotoxins in order of importance:

(i) Heavy metals: such as mercury, lead, cadmium and aluminum.

(ii) Biotoxins: such as tetanus toxin, botulinum toxin (botox), ascaridin (from intestinal parasites), unspecified toxins from streptococci, staphylococci, lyme disease, clamydia, tuberculosis, fungal toxins and toxins produced by viruses. Biotoxins are minute molecules (200-1000 kilodaltons) containing nitrogen and sulfur. They belong to a group of chemical messengers which microorganisms use to control the host's immune system, host behavior and the host's eating habits.

(iii) Xenobiotics (man-made environmental toxins): such as dioxin, phthalates, formaldehyde, insecticides, wood preservatives, PCBs etc.

(iv) Food Preservatives, excitotoxins and cosmetics: such as aspartame (diet sweeteners) food colorings, fluoride, methyl-and propyl-paraben, etc.

I have found that mercury in its different chemical forms has a synergistic amplifying effect with all other neurotoxins. When mercury is removed, the body starts to more effectively eliminate all other neurotoxins, even if they are not addressed.

What are the symptoms?

Any illness can be caused by, or contributed to, or exaggerated by neurotoxins. Fatigue, depression, insomnia, memory loss and blunting of the senses are common early symptoms (see list of mercury related symptoms on the following pages).

How is the diagnosis established?

  1. History of Exposure: (Did you ever have any amalgam fillings? A tick bite? etc)
  2. Symptoms: (How is your short term memory? Do you have areas of numbness, strange sensations, etc?)
  3. Laboratory Testing: (Metals: hair, stool, serum, whole blood, urine analysis, xenobiotics: fatty tissue biopsy, urine. Mold: Immunosciences mold panel)
  4. Autonomic Response Testing: (Dr. Dietrich Klinghardt M.D., Ph.D.)
  5. BioEnergetic Testing (EAV, kinesiology etc.)
  6. Response to Therapeutic Trial
  7. Functional Acuity Contrast Test (measure of Retinal Blood Flow)


Why would we want to treat anyone at all? Is it really needed? Can the body not eliminate these toxins naturally on its own?

Here is a short list of independent risk factors which can either cause accumulation of metals in an otherwise healthy body - or slow down, or inhibit the body's own elimination processes.

• genetics • occupational exposure to toxic material • prior illnesses • surgical operations • medication or ´recreational´ drug use • emotional trauma, especially in early childhood • social status • high carbohydrate intake combined with protein malnutrition (especially in vegetarians) • use of homeopathic mercury • food allergies • the patients electromagnetic environment (mobile phone use, home close to power lines etc) • constipation • compromise of head/neck lymphatic drainage (sinusitis, tonsil ectomy scars, poor dental occusion) • number of dental amalgam fillings over the patients life-time, number of the patients mothers amalgam fillings

We will discuss here only those elimination agents, which are natural, safe and have also been shown to be as effective (or more effective) than the few available pharmaceuticals. Because these products cannot be patented and exploited for unethical personal gain, little attention has been given to them by European or North American medical researchers. Many of the best scientific studies on this topic are from Asian countries.

The Basic Program

1. High protein, mineral, fatty acid and fluid intake

2. ro (Chinese parsley)

This kitchen herb is capable of mobilizing mercury, cadmium, lead and aluminum in both bones and the central nervous system (“Removal and Preconcentration of inorganic and methyl mercury from aequeous media using a sorbent prepared from the plant Coriandrum Sativum”, J of Hazardous Materials B 118 (2005) pp 133-139 D Karunasagar et al).

BioPure cilantro uses a special seed from Brazil that is grown under conditions and in soil that enhances its detox power. It is probably the only effective agent in mobilizing mercury stored in the intracellular space (attached to mitochondria, tubulin, liposomes etc) and in the nucleus of the cell (reversing DNA damage of mercury).

Because cilantro mobilizes more toxins then it can carry out of the body, it may flood the connective tissue (where the nerves reside) with metals that were previously stored in safer hiding places. This process is called re-toxification. It can easily be avoided by simultaneously giving an intestinal toxin-absorbing agent. Our definite choice is the algal organism chlorella. A recent animal study demonstrated rapid removal of aluminum from the skeleton superior to any known other detox agent (Intnl J Acup and Electro-Therapeutics Res, 2003).

Dosage and application of BioPure cilantro tincture: [deleted] Cilantro causes the gallbladder to dump bile - containing the excreted neurotoxins - into the small intestine. The bile-release occurs naturally as we are eating and is much enhanced by cilantro. If no chlorella is taken, most neurotoxins are reabsorbed on the way down the small intestine by the abundant nerve endings of the enteric nervous system). [deleted]

Works most effectively when combined with Toxaway microcurrent foot bath.

Other ways of taking cilantro:

3. Chlorella

Both C.pyreneidosa (better absorption of toxins, but harder to digest) and C.vulgaris (higher CGF content – see below, easier to digest, less metal absorbing capability) are available. A peer-review literature list is available from BioPure. Be aware that there are huge differences in quality. We only recommend BioPure chlorella.

Chlorella has multiple published health inducing effects:

Dosage Chlorella

[deleted] Take 30 minutes before the main meals and at bedtime. This way chlorella is exactly in that portion of the small intestine where the bile squirts into the gut at the beginning of the meal, carrying with it toxic metals and other toxic waste. These are bound by the chlorella cell wall and carried out via the digestive tract.

When amalgam fillings are removed, the higher dose should be given for 2 days before and 2-5 days after the procedure (the more fillings are removed, the longer the higher dose should be given). No cilantro should be given around the time of dental work. During this time we do not want to mobilize deeply stored metals in addition to the expected new exposure. If you take Vitamin C during your detox program, take it as far away from Chlorella as possible (best after meals).

Side effects

Most side effects reflect the toxic effect of the mobilized metals which are shuttled through the organism. This problem is instantly avoided by significantly increasing the chlorella dosage, not by reducing it, which would worsen the problem (small chlorella doses mobilize more metals then are bound in the gut, large chlorella doses bind more toxins then are mobilized). Some people have problems digesting the cell membrane of chlorella. The enzyme cellulase resolves this problem. Cellulase is available in many health food stores in digestive enzyme products. Taking chlorella together with food also helps in some cases, even though it is less effective that way. C.vulgaris has a thinner cell wall and is better tolerated by people with digestive problems. Some manufactures have created cell wall free chlorella extracts (NDF, PCA) which are very expensive, less effective - but easily absorbed.

Chlorella growth factor (CGF)

This is a heat extract from chlorella that concentrates certain peptides, proteins and other ingredients. The research on CGF shows that children develop no tooth decay and their dentition (maxillary-facial development) is near perfect. There are less illnesses and children grow earlier to a larger size with higher I.Q and are socially more skilled. There are case reports of patients with dramatic tumor remissions after taking CGF in higher amounts. In our experience, CGF makes the detox experience for the patient much easier, shorter and more effective.

Recommended dosage: [deleted]

4. Garlic (allium sativum) and wild garlic (allium ursinum)

Garlic has been shown to protect the white and red blood cells from oxidative damage, caused by metals in the blood stream - on their way out – and also has its own valid detoxification functions. Garlic contains numerous sulphur components, including the most valuable sulph-hydryl groups which oxidize mercury, cadmium and lead and make these metals water soluble. This makes it easy for the organism to excrete these substances. Garlic also contains alliin which is enzymatically transformed into allicin, nature's most potent antimicrobial agent.

Metal toxic patients almost always suffer from secondary infections, which are often responsible for part of the symptoms. Garlic also contains the most important mineral which protects from mercury toxicity, bio active selenium. Most selenium products are poorly absorbable and do not reach those body compartments in need for it. Garlic selenium is the most beneficial natural bioavailable source. Garlic is also protectice for against heart disease and cancer.

The half life of allicin (after crushing garlic) is less then 14 days. Most commercial garlic products have no allicin releasing potential left. This distinguishes freeze dried garlic from all other products. Bear garlic tincture is excellent for use in detox, but less effective as antimicrobial agent.

Dosage: [deleted]

5. Fish oil

The fatty acid complexes EPA and DHA in fish oil make the red and white blood cells more flexible thus improving the microcirculation of the brain, heart and other tissues. All detoxification functions depend on optimal oxygen delivery and blood flow. EPA and DHA protect the brain from viral infections and are needed for the development of intelligence and eye-sight. The most vital cell organelle for detoxification is the peroxisome. These small structures are also responsible for the specific job each cell has: in the pineal gland the melatonin is produced in the peroxisome, in the neurons dopamine and norepinephrine, etc. It is here, where mercury and other toxic metal attach and disable the cell from doing its work.

Other researchers have focused on the mitochondria and other cell organelles, which in our experience are damaged much later. The cell is constantly trying to make new peroxisomes to replace the damaged ones– for that task it needs an abundance of fatty acids, especially EPA and DHA. Until recently it was believed, that the body can manufacture its own EPA/DHA from other Omega 3 fatty acids such as fish oil. Today we know that this process is slow and cannot keep up with the enormous demand for EPA/DHA our systems have in today's toxic environment. Fish oil is now considered an essential nutrient, even for vegetarians. Recent research also revealed that the transformation humans underwent when apes became intelligent and turned into humans happened only in coastal regions, where the apes started to consume large amounts of fish. Why not benefit from that knowledge and consume more fish oil?

The fatty acids in fish oil are very sensitive to exposure to electromagnetic fields, temperature, light and various aspects of handling and processing. Trans fatty acids, long chain fatty acids, renegade fats and other oxidation products and contaminants are frequently found in most commercial products. Ideally, fish oil should be kept in an uninterrupted cooling chain until it ends up in the patient's fridge. The fish-source should be mercury and contaminant free, which is becoming harder and harder. Fish oil should taste slightly fishy but not too much. If there is no fish taste, too much processing and manipulation has destroyed the vitality of the oil. If it tastes too fishy, oxidation products are present. I recommend to use the product recommended below (grade I), where meticulous care has been taken to comply with all the necessary parameters. The clinical results are outstanding.

Dosage: [deleted]

The VegiPearls contain half the amount of EPA/DHA. The vegetarian capsules eliminate even the most remote possibility of containing prions and make the idea of taking fish oil more easily acceptable for vegetarians. Recently a fatty acid receptor has been discovered on the tongue, joining the other more known taste receptors. If the capsules are chewed, the stomach and pancreas start to prepare the digestive tract in exactly the right way to prepare for maximum absorption. Children love chewing the VegiPearls.

To treat bipolar depression, post partum depression and other forms of mental disease, 2000 mg of EPA are needed/day (David Horrobin). For the modulation of malignancies, 120 mg of EPA 4 times/day are needed. The calculations can easily be done with the information given on the label.

Matrix Electrolytes (ME) The autonomic nervous system in most toxic patients is dysfunctional. Electric messages in the organism are not received, are misunderstood or misinterpreted. Toxins cannot be shuttled through the extracellular space. Increased intake of natural ocean salt (celtic sea salt) – and avoidance of regular table salt - has been found to be very effective in resolving some of these problems. Most effective is a solution pioneered by the American chemist Ketkovsky. He created the formula for the most effective electrolyte replacement, which was further improved by our research team and is available under the name “Matrix Electrolyte”. I recommend this to all my patients and have observed, that every aspect of the detoxification process seems to be enhanced. Dramatically enhances the absorbtion and clinical effectiveness of herbs when given together with ME.

Five percent of the population is sodium or chloride sensitive – the blood pressure goes up (easily reversible). In these patients the detox process takes longer and is more difficult. Dosage: 1 tsp in a cup of good water 1-3 times/day Gradually increase the dosage to 1 tbsp 3 times/day.

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Detox has to be done carefully and right!

October 2002 - 2nd edition Jan 2006
Dietrich Klinghardt, MD, PhD
Bellevue, Washington, USA


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